Breakthrough Covid infections three times higher in immunocompromised people – study


Coronavirus infections in fully vaccinated people are rare but are more common and more serious in people with weaker immune systems, a new study has suggested.

Researchers analyzed health records and found that only 0.08% of people in their fully vaccinated group had a breakthrough infection between December 10, 2020 and July 8, 2021.

They also found that although immunocompromised people made up 18% of those studied, they accounted for over 38% of infections, almost 60% of all hospital admissions, and 100% of deaths.

According to the study, the proportion of people with breakthrough infections was three times higher in immunocompromised people (0.18%) than in the comparison group of non-immunocompromised people (0.06%).

Manuela Di Fusco, lead author of Pfizer Health’s Economics and Outcomes Research Team, said: “The findings complement other real-world studies and support the introduction of a third dose of a Covid-19 vaccine to increase protection among immunocompromised individuals.

“Several countries are currently experiencing a resurgence of Sars-CoV-2 infections despite the deployment of mass vaccination programs.

“While Covid-19 mRNA vaccines help protect people against infection and serious illness, the risk of major infections in fully vaccinated people is not completely eliminated. “

By identifying individuals in the U.S. population who had received two doses of the Pfizer / BioNTech vaccine, the Pfizer study aimed to examine breakthrough infections in people with and without weakened immune systems.

The team analyzed the medical records of 1,277,747 people aged 16 or older who had received two doses of the vaccine.

Of this group, 225,796 (17.7%) were identified as immunocompromised – including people with advanced HIV / AIDS, cancer, kidney disease, rheumatologic or other conditions. inflammatory diseases, other immune disorders, and bone marrow or organ transplant recipients.

Ms. Di Fusco added, “The results of our study advance the understanding of post-vaccination outcomes and support recent recommendations to provide a third primary serial dose of a Covid-19 mRNA vaccine to patients with immune systems. is lower after the first two doses. “

The results come as the UK Joint Committee on Vaccination and Immunization (JCVI) announced that severely immunocompromised people should be offered a booster dose no earlier than three months after completing their primary three-dose cycle.

The research is published in the Journal of Medical Economics.

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